中国当代医药Issue(13)：8-11,4.
局部进展期胃癌术后同步放化疗近期疗效与毒副作用分析
Analysis of short-term effect and toxic and side effect by concurrent ra-diochemotherapy after surgery of locally advanced gastric carcinoma
摘要
Abstract
Objective To explore the influence of 2-year survival rate and short-term toxic and side effects in patients with stage II-Ⅲ gastric cancer after surgeries by concurrent radiochemotherapy and only chemotherapy. Methods 49II-Ⅲ stage gastric cancer patients admitted into our hospital and undergone radical operation from February 2010 to June 2012 were retrospectively analyzed.According to different therapeutic regimens,they were divided into two groups:concurrent radiochemotherapy after surgery group and only chemotherapy after surgery group.In the former group(n=24), XELOX regimen of chemotherapy was used for two weeks,and oral administration of capecitabine (825 mg/m2)twice per day for radiotherapy,and finally for two-week chemotherapy after radiotherapy was finished.In the latter one (n=25, XELOX regimen of chemotherapy was adopted for 4 to 6 weeks.The 2-year survival rate,survival rate without recur-rence,toxic and side effects during treatment were compared by regular follow up. Results The 2-year survival rate in concurrent chemoradiotherapy group and only chemotherapy group was 87.5% and 64.0% respectively.The survival rate of recurrence-free within 2 years in both groups was 70.8%and 48.0% respectively,with statistical difference (P<0.05). There was no significant difference in hematological toxicity,gastrointestinal reaction and hand-foot syndrome between two groups. Conclusion Concurrent chemoradiotherapy after operation for gastric carcinoma at stages ofII-Ⅲ can im-prove 2-year survival rate and survival rate of recurrence-free with tolerant toxic and side effect.关键词
胃癌/术后同步放化疗/术后化疗/2年生存率/毒副作用Key words
Gastric cancer/Concurrent chemoradiotherapy after surgery/Postoperative chemotherapy/2-year survival rate/Toxic and side effect分类
医药卫生引用本文复制引用
王燕,许刚,吴立广,吴朝阳..局部进展期胃癌术后同步放化疗近期疗效与毒副作用分析[J].中国当代医药,2015,(13):8-11,4.基金项目
江苏省镇江市科学技术成果项目 （）
