摘要
Abstract
Objective To explore the relationship between non-alcoholic fatty liver disease (NAFLD) and small intesti-nal bacterial overgrowth (SIBO) and further get known the incidence of SIBO in NAFLD patients and influences of in-testinal endotoxemia (IETM) on tumor necrosis factor-α (TNF-α) and liver fibrosis aiming at evaluating its role in the occurrence and development of NAFLD. Methods 32 patients diagnosed as NAFLD by B ultrasound and medical histo-ry in our hospital from February to August 2013 were selected.They were performed with lactulose hydrogen breath test (LHBT).According to LHBT outcomes,these participants were divided into SIBO positive group and SIBO negative group.Indicators of IETM,TNF-α,and liver fibrosis was tested respectively. Results There were statistical differences in IETM and TNF-α after comparisons between two groups.In SIBO positive group,TNF-α and liver fibrosis gradually in-creased,which both had positive correlations with IETM. Conclusion Mechanisms of SIBO and IETM both promote the occurrence and development of NAFLD.关键词
非酒精性脂肪性肝病/呼吸试验/小肠细菌过度生长/肝纤维化Key words
Non-alcoholic fatty liver disease (NAFLD)/Breath test/Small intestinal bacterial overgrowth(SIBO)/Hepatic fibrosis分类
医药卫生
