摘要
Abstract
Objective To explore the clinical effect and safety of doxofylline and aminophylline in the treatment of bronchial asthma. Methods From April 2013 to April 2014,84 patients with bronchial asthma admitted into our hospital were selected as research objects.By simple sampling method,they were evenly divided into doxofylline group (group A) and aminophylline group (group B).Both groups was given conventional therapy.In group A,4.7 mg/kg as an initial dose of doxofylline injection and 0.55 mg/(kg·h) as a continuous dose by intravenous injection was given while in group B, 100-200 mg aminophylline tablets every time for oral administration were given.Change of pulmonary ventilation func-tion before and after treatment between two groups was compared,and clinical therapeutic effect and incidence rate of adverse reaction were recorded. Results After 7 days treatment,indexes of pulmonary ventilation function in both groups greatly improved compared with those before treatment (P<0.05).In group A,indexes of tidal volume (TV),total lung ca-pacity (TLC),and vital capacity (VC) [ (563.3±89.3) ml,(437.4±68.4) ml,and (2989.3±534.2) ml respectively] was more than that of group B (P<0.05).The number of clinical control was 19 in group A and the total effective rate (85.7%) was higher than that in group B (61.9%) (P<0.05).There was no severe adverse reaction occurred in two groups.The inci-dence rate of mild adverse reaction (9.5%) in group A was lower than that in group B (42.9%) (P<0.05). Conclusion Intravenous injection of doxofylline for patients with bronchial asthma can obtain a exact effect.It is worthy of clinical expansion.关键词
多索茶碱/氨茶碱/支气管哮喘/临床效果/安全性Key words
Doxofylline/Aminophylline/Bronchial asthma/Clinical effect/Safety分类
医药卫生
