摘要
Abstract
Objective To assess the efficacy and safety of proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RAs) for the prevention of stress ulcer in acute myocardial infarction patients. Methods Trails were identified by searching PubMed Central,WanFang Full-text Database and CNKI large databases(1992 to December 2013).All the rel-evant randomised controlled trials were collected.Two reviewers assessed the quality of studies and extracted date in-dependently.Disagreement was resolved by discussion.The outcomes were incidence of SU,mortality and adverse events. RevMan 5.2 software was used for meta-analyses. Results Six trails involving 948 patients were included.Most of the trails were poor quality.Meta-analyses showed that PPIs and H2RAs significantly less stress ulcer [OR=0.22,95%CI (0.12,0.38),P<0.01],but there was no significant difference in the ortality [OR=0.76,95%CI (0.22,2.60),P=0.67] and ad-verse events[OR=0.84,95%CI(0.56,1.28),P=0.42]. Conclusion PPIs and H2RAs may significantly reduce the incidence of stress ulcer,but cannot reduce the mortality and increase the incidence of adverse events.关键词
急性心肌梗死/应激性溃疡/质子泵抑制剂/H2受体阻滞剂/Meta分析Key words
Acute myocardial infarction/Stress ulcer/PPIs/H2RAs/Meta-analysis分类
医药卫生
