中国健康心理学杂志Issue(7)：964-966,3.DOI:10.13342/j.cnki.cjhp2.015.07.002
奥氮平和帕利哌酮对首发精神分裂症患者的糖代谢影响
Effects of Olanzapine and Paliperidone on the Glucose Metabolism in First-episode Schizophrenic Patients
摘要
Abstract
Objective:To investigate the effects of olanzapine and paliperidone on the glucose metabo-lism in schizophrenic patients.Methods:Seventy-six first-episode schizophrenic were randomly divid-ed into two groups,which treated with olanzapine and paliperidone respectively.Before and after 4-week treatment,all the patients were given oral glucose tolerance test(OGTT),and the blood glucose values were measured.The fasting serum insulin,C-peptide,cholesterol,triglyceride,and leptin concentration were also measured.The Body Mass Index( BMI) was calculated for each patient.Results:In the OGTT, after 4-week treatment,the blood glucose at the time-points of 1 and 2 hour were higher than the base-line in olanzapine group(t=2.47,4.75;P<0.05),but unchanged in paliperidone group.The rate of im-paired glucose tolerance ( IGT ) was higher in olanzapine group than that in paliperidone group (χ2 =4.542,P<0.05).Conclusion:Olanzapine has stronger effect than paliperidone on the glucose metabo-lism.关键词
奥氮平/帕利哌酮/精神分裂症/血糖/糖耐量试验Key words
Olanzapine/Paliperidone/Schizophrenia/Blood sugar/Glucose tolerance test分类
医药卫生引用本文复制引用
刘毅,廖世棚,戢秋明,李驰..奥氮平和帕利哌酮对首发精神分裂症患者的糖代谢影响[J].中国健康心理学杂志,2015,(7):964-966,3.
