健康研究Issue(3)：251-253,3.DOI:10.3969/j.issn.1674-6449.2014.03.005
雷奈酸锶防治大鼠失用性骨质疏松的研究
The effects of strontium ranelate in preventing disuse-induced osteoporosis in rat
摘要
Abstract
Objective To understand the effects of strontium ranelate on bone mass , bone matablism and biomechanical properties of osteoporotic rats induced by disuse .Methods 24 3-month old SD rats were randomized into 3 groups of 8 animals each:Normal control group ( A) , osteoporosis group ( B) , and strontium ranelate treatment group ( C) .Rats in group B and C were subjected to tail suspension , and rats in group C were administered with strontium ranelate (1g/kg/d).All rats were sacrificed 4 weeks later .Content of P1NP in blood serum and DPYD/Cr, NTX/Cr in urine were detected .The right tibias were prepared for undecalcified sections and thereby bone histomorphometry analysis , and right femurs were collected for bone mineral density assessment , three-point bending test was performed on left femurs to assess the maximum load . Results 1.P1NP concentration in group B was significantly lower than that of group A and C .Tail suspension markedly increased the levels of DPYD/Cr and NTX/Cr.Strontium ranelate could retard the increase but still significantly higher than those of normal rats (P <0.05); 2.Trabecular volume, number, thickness, and bone formation rate in group B were significantly lower than those in group A and C , while the osteoclast number and erosion percentage were markedly higher in group B, as compared to those of group A and C (P<0.05);3.Bone mineral density in group A, C and B showed a subsequently decreasing manner , with significant difference between any two groups ( P <0.05 ); 4.The results of biomechanical test showed markedly lower maximum load in group B as compared to group A (P<0.05).Conclusion Strontium ranelate could partially prevent the deterioration of bone quality and biomechanical property in disuse -induced osteoporosis rat .关键词
雷奈酸锶/失用性骨质疏松/骨代谢/骨密度/骨组织形态计量学/生物力学Key words
strontium ranelate/disuse-induced osteoporosis/bone metablism/bone mineral density/bone histomorphometry/biomechanics分类
医药卫生引用本文复制引用
卢继华,胡东,邢磊..雷奈酸锶防治大鼠失用性骨质疏松的研究[J].健康研究,2014,(3):251-253,3.基金项目
河北省卫生厅医学科学研究重点课题计划资助项目 （）
