健康研究Issue(1)：20-22,3.DOI:10.3969/j.issn.1674-6449.2015.01.008
基于肾上腺切除+自体大网膜移植的雄激素全阻断大鼠模型的建立
Androgen deprivation rat modeling by removing adrenalines and autologous ectopic transplanting
摘要
Abstract
Objective To establish androgen deprivation rat modeling by removing rat testicles and bilateral adrenalines and autologous ectopic transplanting so as to obtain scientific knowledge for treating prostate cancer .Methods 32 SA rats were randomly divided into four groups , namely, group A, B, C, and D.Treatment for group A included removal of testicles , removal of bilateral adrenal , and transplanting adrenal cortical tissue under autologous epiploon .Treatment for group B included removal rat testicles .Treatment for group C included removal of bilateral adrenalines and implanting adrenal cortical tissue under autologous epiploon .Treatment for group D included sham operation .Findings The prostate of group A atrophied evidently , greater omentum implant survived and regenerated with endocrine function .Conclusion Androgen deprivation by means of removal of testicles and bilateral adrenalines and autologous epiploon transplanting can make an effective method for treating prostate cancer .关键词
雄激素全阻断/睾丸/肾上腺/自体异位移植/大鼠Key words
androgen deprivation/testicles/adrenaline/autologous ectopic transplantation/rats分类
医药卫生引用本文复制引用
徐媛,尹洪萍,周威,金良,亢晓冬..基于肾上腺切除+自体大网膜移植的雄激素全阻断大鼠模型的建立[J].健康研究,2015,(1):20-22,3.基金项目
浙江省新苗人才计划项目（2012R421012）；浙江省“挑战杯”大学生课外学术科技作品竞赛 （）
