健康研究Issue(2)：145-147,150,4.DOI:10.3969/j.issn.16746-449.2015.02.010
2型糖尿病气阴两虚证和血瘀脉络证尿液代谢组学研究
Urinary metabolomic study of Qi-Yin deficiency syndrome and blood stasis syndrome of type 2 diabetes mellitus
摘要
Abstract
Objective To find out the difference in metabolism between type 2 diabetes mellitus's patients with syndrome of Qi-yin deficiency and those with blood stasis syndrome.Method 10 patients of Type 2 diabetes mellitus's patients with Qi-Yin deficiency syndrome and 10 cases of blood stasis syndrome were chosen as the experimental group.10 healthy persons were chosen as the control group ( n=10 ) .The urine samples of both groups were then subjected to analysis with Gas Chromatography-Mass Spectrometry ( GC-MS) .The potential biomarkers were then inspected.Findings Type 2 diabetes mellitus's patients were found to have disorder of glucose metabolism and amino metabolism .As compared with the control group,the experimental group were found to have increased level of d -galactose and glycine (P<0.01) .The content of D-glucose,inositol and glycine was found to have increased in the blood stasis syndrome group (P<0.05 or P<0.01). Conclusion The difference is significant in urine metabolism between the Qi-Yin deficiency syndrome group and the blood stasis syndrome group of patients of type 2 diabetes mellitus.These metabolites may be the potential metabolic marker for TCM pattern in identifying type 2 diabetes mellitus with both Qi-Yin deficiency syndrome and blood stasis syndrome.关键词
代谢组学/2型糖尿病/气阴两虚证/血瘀脉络证/气相色谱-质谱联用Key words
metabonomics/type 2 diabetes mellitus/Qi-Yin deficiency syndrome/blood stasis syndrome/GC-MS分类
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苏君梅,葛卫红..2型糖尿病气阴两虚证和血瘀脉络证尿液代谢组学研究[J].健康研究,2015,(2):145-147,150,4.基金项目
浙江省钱江人才计划 （）
