解剖学杂志Issue(3)：279-283,5.DOI:10.3969/j.issn.1001-1633.2015.03.006
负极性聚丙烯驻极体对糖尿病大鼠皮肤结构的影响
Effects of negative electrets on skin structure of diabetic rats
摘要
Abstract
Obj ective :The purpose of this study was to evaluate the stability of the electrostatic field on both sides of the skin in diabetic rats generated by negative electret.And the effects of skin structure were investigated after different surface potential electrets.This paper for more scientifically,discussed the transdermal delivery mechanism of negative electrets.Methods :Polypropylene (PP)electret was prepared with a corona charging system under different charging conditions.The surface potential of the electrets as measured using a surface potentiometer.Equivalent surface potential decay was measured and the optical microscope was used to evaluate the stability of the electret field on both sides of the skin and the skin microstructure by the effect of electret.Results :(1 )The surface potential of the electret could penetrate through the diabetic rat skin after 2 4 h continuous function and stayed about 6 8 % of the initial surface potential.It means that the skins of diabetic rat could be in a stable electrostatic field.(2 )Stratum corneum and full leather of the diabetic rats skin became thicker and thicker with the- 1 5 0 0 V electret.The epidermis and dermis cells arranged mare clearly than the diabetic control rats,but the arrangement was relatively looser after - 1 5 0 0 V electret’s action.At the same time,the atrophy area of hypodermis restored partially. Conclusion:(1 )Negative electret can provide a certain size electrostatic field for both sides of the skin of diabetic rats. (2 )Electrostatic field generated by electret can improve the microstucture and loosen the stratum corneum and dermis cells of diabetic rats’skin.Electret is expected to be used for transdermal drug preparation.关键词
聚丙烯/驻极体/皮肤结构/糖尿病大鼠/透皮给药/静电场Key words
polypropylene/electret/skin structure/diabetic rats/transdermal administration/electrostatic field引用本文复制引用
王美玲,苑旺,梁媛媛,李鹏飞,许佳捷,崔黎丽,江键..负极性聚丙烯驻极体对糖尿病大鼠皮肤结构的影响[J].解剖学杂志,2015,(3):279-283,5.基金项目
国家自然科学基金(50977089) （50977089）
