江苏大学学报（医学版）Issue(6)：497-500,4.DOI:10.13312/j.issn.1671-7783.y140184
西格列汀对2型糖尿病合并颈动脉硬化患者氧化应激指标和内皮素的影响
Effects of sitagliptin on oxidative stress and endothelin-1 in diabetic patients with carotid atherosclerosis
冯亚敏 1鲁一兵 1缪珩 1金俊飞 2祝群1
作者信息
- 1. 南京医科大学第二附属医院内分泌科，江苏 南京 210011
- 2. 桂林医学院附属医院肝胆胰外科实验室，广西 桂林 541001
- 折叠
摘要
Abstract
Objective:To investigate the effects of sitagliptin on oxidative stress and endothelin-1 (ET-1 )in type 2 diabetic patients with carotid atherosclerosis.Methods:Sixty-two type 2 diabetic patients with carotid atherosclerosis were randomly divided into sitagliptin group(n =32)and control group (n =30). Patients in sitagliptin group taken sitagliptin 1 00 mg per day with their currently hypoglycemic drug treat-ment(dosage of insulin reduced)and patients in control group continued their hypoglycemic drug treatment. Malonaldehyde (MDA),the marker of oxidative stress,superoxide dismutase (SOD)and endothelin-1 (ET-1 )from the two groups (pre-and post-treatment)were determined and compared.Results:There were no significant differences in the levels of ET-1 ,MDA and SOD between two groups before treatment. After treatment,the levels of ET-1 and MDA in sitagliptin group were significantly decreased (P <0.01 ), and the activity of SOD was significantly increased (P <0.01 ).There were no significant differences in the levels of ET-1 ,MDA and SOD in control group between pre-treatment and post-treatment (P >0.05 ). Conclusion:Sitagliptin has good effects on decreasing levels of oxidative stress and ET-1 ,which might pro-tect from the diabetic macrovascular complications.关键词
2 型糖尿病/颈动脉硬化/氧化应激/西格列汀Key words
type 2 diabetes/carotid atherosclerosis/oxidative stress/sitagliptin分类
医药卫生引用本文复制引用
冯亚敏,鲁一兵,缪珩,金俊飞,祝群..西格列汀对2型糖尿病合并颈动脉硬化患者氧化应激指标和内皮素的影响[J].江苏大学学报（医学版）,2014,(6):497-500,4.
