江苏大学学报（医学版）Issue(3)：225-228,4.DOI:10.13312/j.issn.1671-7783.y150015
结直肠腺癌组织 Caveolin-1表达与微淋巴管密度的关系及临床意义
Correlation of Caveolin-1 expression with microlymphatic density in colorectal adenocarcinoma tissues and its clinical significance
摘要
Abstract
Objective:To study the expression of Caveolin-1 in colorectal adenocarcinoma tissues and its correlation with microlymphatic density (LMVD),and to investigate the clinical pathological prognostic sig-nificance of Caveolin-1 and LMVD in patients with colorectal cancer.Methods:The expression of Caveo-lin-1 and LMVD in 45 specimens of normal colorectal tissues,and 90 specimens of colorectal adenocarcino-ma tissues were detected by immunohistochemistry technique.We also investigated the correlation between their expression and the clinicopathologic tissues features.Results:The positive rates of Caveolin-1 in colo-rectal adenocarcinoma (73.33%) were significantly higher than those in normal colorectal tissues (1 1 .1 1 %,P <0.01 );The positive rates of LMVD in colorectal adenocarcinoma tissues (1 8.25 ±2.36) were significantly higher than those in normal colorectal tissues (3.1 4 ±1 .58,P <0.01 ).Expression of Caveolin-1 and LMVD value was correlated with liver metastasis,lymph node metastasis,TNM stage and the depth of tumor invasion.The mean LMVD in group with Caveolin-1 positivity expression was significantly higher than in that with Caveolin-1 negativity expression.Conclusion:The expression of Caveolin-1 in colorectal cancer was closely related to lymphatic microvessel of tumor,and its expression and LMVD were independent prognostic indicators for patients with colorectal cancer.关键词
结直肠腺癌/Caveolin-1/微淋巴管密度/免疫组织化学Key words
colorectal neplasms/Caveolin-1/microlymphatic density/immunohistochemistry分类
医药卫生引用本文复制引用
郭飞,薛军,武雪亮,宇宏峰,屈明,张鹏程,孙光源,胡晓峰,王立坤..结直肠腺癌组织 Caveolin-1表达与微淋巴管密度的关系及临床意义[J].江苏大学学报（医学版）,2015,(3):225-228,4.基金项目
张家口市科技局2013指令性计划 （）
