江苏大学学报（医学版）Issue(3)：241-245,5.DOI:10.13312/j.issn.1671-7783.y150064
肝内胆管结石相关性肝内胆管细胞癌的临床病理特征及预后分析
Analysis of clinicopathological and prognostic characteristics in hepatolithiasis-associated intrahepatic cholangiocarcinoma
摘要
Abstract
Objective:To describe the difference between the hepatolithiasis(HL)-positive intrahepatic cholangiocarcinoma(ICC)and hepatolithiasis-negative intrahepatic cholangiocarcinoma,and examine the prognosis based on our data.Methods:A total of 296 patients with ICC underwent the first curative resec-tion were involved in our research,in whom 38 were with hepatolithiasis ,the rest 258 were without.Data of sixteen clinicopathological features,recurrence free survival(RFS)rate and overall survival(OS)rate were collected and examined retrospectively.Results:About the sixteen clinicopathological features,the age of the HL-associated ICC patients tend to be older and with more female gender.The HL-positive group tends to have a higher level of CA1 9-9,ALP,r-GT.Meanwhile,the HL-positive ICC was more likely to be accompanied with satellite lesions,lymph node metastasis,nerve invasion.Moreover,the HL-positive ICC tends to have a more progressive TNMstaging.The actual 1 -,3-,5-year recurrence free survival(RFS)rate in the HL-positive group was 1 9.8%,2.6%,0% and in the HL-negative group was 46.9%,26.4%, 20.9%.The 1 -,3-,and 5-year overall survival rate was 39.5%,7.9%,0% in the HL-positive group and in the HL-negative group was 67.8%,38.0%,26.4%.Conclusion:The HL-positive ICC has a more pro-gressive degree and a poorer prognosis compared with the HL-negative ICC.So that the HL-positive ICC were prone to form the lymph node metastasis,and lymphadenectomy in the hepatoduodenal ligament was suggested.关键词
肝内胆管细胞癌/肝内胆管结石/预后/生存率Key words
intrahepatic cholangiocarcinoma/hepatolithiasis/survival分类
医药卫生引用本文复制引用
宿鑫成,庞书杰,杨宁,许朱定,张海斌,付雍,杨广顺..肝内胆管结石相关性肝内胆管细胞癌的临床病理特征及预后分析[J].江苏大学学报（医学版）,2015,(3):241-245,5.基金项目
国家十二五艾滋病和病毒性肝炎等重大传染病防治专项课题 （）
