江苏大学学报（医学版）Issue(3)：256-259,4.DOI:10.13312/j.issn.1671-7783.y140321
硫酸铵梯度法制备重酒石酸长春瑞滨脂质体及其在大鼠体内的药动学参数
Preparation and pharmacokinetics in rat of vinorelbine biartrate liposomes by ammonium sulfate gradient method
郑召磊 1李亚平 1陈伶俐2
作者信息
- 1. 江苏大学药学院，江苏 镇江 212013
- 2. 中国科学院上海药物研究所药物制剂中心，上海 201203
- 折叠
摘要
Abstract
Objective:To prepare vinorelbine bitartrate(NVB)liposomes by ammonium sulfate gradient method,and to study the properties and pharmacokinetics of NVB liposomes.Methods:NVB liposomes were prepared by ammonium sulfate gradient method.The mean diameter of liposomes was determined by dynamic light scattering.Encapsulation efficiency was determined by sephadex column,pharmacokinetics was evaluated in SD rats.Results:Mean particle size and encapsulation efficiency of NVB liposomes were (88.7 ±1 1 .2)nm(n =3)and (90.71 ±0.1 6)%(n =3).In addition,less than 20% of NVB liposomes was released in 48 hours.The main pharmacokinetic parameters of NVB liposomes were as follows:t1 /2 =(5.38 ±0.29)h and AUC0→t =(98.1 1 ±0.1 2)mg·h -1 ·L -1 .Conclusion:NVB liposomes exhibited high encapsulation efficiency.The pharmacokinetics of NVB liposomes showed prolonged elimination half-life and increased bioavailability.关键词
重酒石酸长春瑞滨/脂质体/硫酸铵梯度法/药动学Key words
vinorelbine biartrate/liposomes/ammonium sulfate gradient method/pharmacokinetics分类
医药卫生引用本文复制引用
郑召磊,李亚平,陈伶俐..硫酸铵梯度法制备重酒石酸长春瑞滨脂质体及其在大鼠体内的药动学参数[J].江苏大学学报（医学版）,2015,(3):256-259,4.
