实用临床医药杂志Issue(5)：27-29,3.DOI:10.7619/jcmp.201405009
辛伐他汀联合氯吡格雷对不稳定型心绞痛患者 IL-6、hs-CRP 及预后的影响
Influence of simvastatin combined with clopidogrel on IL-6,hs-CRP and prognosis of patients with unstable angina pectoris
苗伟 1宋辉 1李震花 1张雪晶1
作者信息
- 1. 山东省济南市中心医院，山东 济南，250013
- 折叠
摘要
Abstract
Objective To explore the influence of simvastatin combined with clopidogrel on prognosis and levels of IL-6 and hs-CRP CRP in patients with unstable angina pectoris (UAP). Methods 105 patients with UAP from January 2011 to January 2013 were randomly divided into observation group (n =53)and control group (n =52).On the basis of conventional treatment, control group was treated with clopidogrel,while observation group was treated with simvastatin plus clopidogrel.Clinical efficacy,levels of IL-6 and hs-CRP and cardiovascular events were com-pared between two groups.Results The total effective rate was 59.6% in the control group, which was significantly lower than 86.8% in the observation group (P <0.01).After treatment, levels of IL-6 and hs-CRP decreased significantly in both groups (P <0.05),and there were signifi-cant differences between two groups (P <0.05).All the patients were followed up for 30 days,and there were significant differences in aspect of incidence of postoperative angina and myocardial in-farction between two groups (P <0.05).Conclusion Calcium clopidogrel combined with simvas-tatin can effectively improve levels of IL-6 and hs-CRP in the treatment of patients with UAP.关键词
辛伐他汀/氯吡格雷/不稳定型心绞痛/疗效/IL-6/hs-CRPKey words
simvastatin/clopidogrel/unstable angina pectoris/efficacy/Interleukin-6/high-sensitivity C-reaction protein分类
医药卫生引用本文复制引用
苗伟,宋辉,李震花,张雪晶..辛伐他汀联合氯吡格雷对不稳定型心绞痛患者 IL-6、hs-CRP 及预后的影响[J].实用临床医药杂志,2014,(5):27-29,3.
