实用临床医药杂志Issue(5)：67-69,86,4.DOI:10.7619/jcmp.201405022
新辅助化疗两种方式治疗局部晚期宫颈癌疗效及安全性比较
Efficacy and safety comparison between two neo-adjuvant chemotherapies in treatment of locally advanced cervical carcinoma
摘要
Abstract
Objective To compare the efficacy and safety of intravenous chemotherapy plus operation and interventional arterial chemotherapy plus operation in treatment of patients with local-ly advanced cervical carcinoma (phases Ib2~IIb).Methods 140 patients with locally advanced cervical carcinoma (phases Ib2~IIb)were divided into experimental group (uterine artery interven-tional chemotherapy plus surgery)and control group (venous chemotherapy plus surgery)according to different initial therapeutic methods,70 cases in each group.Short-term efficacy,tumor diameter changes before and after treatment,rate of radical operation,3 and 5 years overall survival (OS), progression-free survival (PFS),complications as well as pathological risk factors (rates of para-u-terine invasion and lymph node metastasis)were observed.Results Short-term efficacy improved in both groups.The decreased tumor diameter in experimental group was significantly greater than control group,and the probability rate of patients with radical operation was significantly larger than the control group.Corresponding rates of para-uterine invasion and lymph node metastasis in the ex-perimental group were significantly lower than the control group.There were no significant differ-ences of 3 years OS and PFS between two groups,and the 5 years OS and PFS in the experimental group were higher than the control group.Conclusion For patients with locally advanced cervical carcinoma,neo-adjuvant chemotherapy with artery interventional therapy is better than intravenous chemotherapy in aspects of surgical resection rate and 5 years OS,so it is a safe and effective thera-peutic method.关键词
新辅助化疗/动脉介入/宫颈癌/局部晚期Key words
neo-adjuvant chemotherapy/artery intervention/cervical carcinoma/locally advanced分类
医药卫生引用本文复制引用
刘翠,罗常华,蒋绍莉,李秋涟..新辅助化疗两种方式治疗局部晚期宫颈癌疗效及安全性比较[J].实用临床医药杂志,2014,(5):67-69,86,4.基金项目
中国高校医学期刊临床专项资金 （）
