实用临床医药杂志Issue(5)：93-95,3.DOI:10.7619/jcmp.201405031
氟达拉滨治疗慢性淋巴细胞白血病的疗效及其对生存率的影响
Effect of fludarabine on treatment of patients with chronic lymphocytic leukemia and its influence on survival rate
姜铧 1龙志国 1张霞 1夏云金 1章正华 1万楚成1
作者信息
- 1. 湖北医药学院第一临床学院 十堰市太和医院 血液内科，湖北 十堰，442000
- 折叠
摘要
Abstract
Objective To explore the effect of fludarabine on treatment of patients with chronic lymphocytic leukemia (CLL)and its influence on survival rate.Methods 32 elderly pa-tients with CLL were treated with fludarabine,and they were also divided into stage 0~Ⅱ (n =17)group and stage Ⅲ~Ⅳ (n =15)group according to clinical stage of disease.30 elderly pa-tients with medical examination were designed as control group.Number of peripheral blood lym-phocyte were compared between 3 groups,and the relationship between complete remission rate and the clinical related factors as well as survival rate within post-treatment 3 years in CLL pa-tients were observed.Results The number of CD4+ T cells in the control group was significantly higher than that in the stage Ⅲ~Ⅳ group (P <0.01).The number of CD4+ /CD8+ in the control group was significantly higher than that in the treatment group(P <0.05).There was a close rela-tionship between the complete remission rate of fludarabine treatment and the patient’s age,stag-ing and course of treatment.The survival rate within post-treatment 3 years was 65.6%.Con-clusion Fludarabine can significantly improve the patients′immune status and increase the com-plete remission rate and survival rate.关键词
氟达拉滨/慢性淋巴细胞白血病/疗效Key words
fludarabine/chronic lymphocytic leukemia/efficacy分类
医药卫生引用本文复制引用
姜铧,龙志国,张霞,夏云金,章正华,万楚成..氟达拉滨治疗慢性淋巴细胞白血病的疗效及其对生存率的影响[J].实用临床医药杂志,2014,(5):93-95,3.
