实用临床医药杂志Issue(9)：22-26,5.DOI:10.7619/jcmp.201409006
江苏省南京地区肺炎链球菌对β-内酰胺类抗生素耐药及传播机制
Resistance and transfer mechanism of β-lactam resistant streptococcus pneumoniae isolates in Nanjing area
摘要
Abstract
Objective To explore the prevalence,mechanism and dissemination of β-lactam resistant streptococcus pneumoniae isolates in Nanjing area.Methods A collection of 130 strains of streptococcus pneumoniae isolated from seven teaching hospitals in Nanjing between 2010 and 2012 were included in this study.MICs of 14 common antibiotics were determined by agar dilution test. pbp1A、pbp2B、pbp2X genes were amplified.All the isolates were analyzed by pbp fingertyping to e-valuate their gene relateness. Results The resistance rates of clinical isolates to penicillin, cefuroxime ,cefotaxime ,cefepime ,ceftiaxone ,amoxicillin and meropenem were 5 1 .5 % ,6 9 .2 % , 17.7%,12.3%,3.1%,6.2%,16.9% respectively.The penicillin resistant rate in children was higher than that in adult.A good correlation had been found between penicillin and cefuroxime, cefepime,amoxicillin.5 isolates exhibited type A1-B1-X1 in molecular typing might be the same clone.Conclusion The penicillin resistant rate in children is high,a small range of clone dissemina-tion is found in Nanjing.关键词
肺炎链球菌/β-内酰胺类抗生素/RFLP/传播机制Key words
streptococcus pneumonia/β-lactam antibiotics/RFLP/dissemination mecha-nism分类
医药卫生引用本文复制引用
丁晶晶,苗立云,李燕,蔡后荣..江苏省南京地区肺炎链球菌对β-内酰胺类抗生素耐药及传播机制[J].实用临床医药杂志,2014,(9):22-26,5.基金项目
江苏省南京市卫生人才科研资助项目（2011868）；中央高校基本科研资助项目 （）
