实用临床医药杂志Issue(13)：4-6,3.DOI:10.7619/jcmp.201413002
脑线粒体形态和呼吸链参与D-半乳糖诱导脑衰老的研究
Brain mitochondrial dysfunction in D-galactose-induced brain aging
摘要
Abstract
Objective To observe the involvement of mitochondrial dysfunction in D-gal-in-duced aging model.Methods Respiratory chain activities (complex Ⅰ,Ⅱ,Ⅲ and Ⅳ)in brain mitochondria and ultrastructural impairments of hippocampal mitochondria were examined in the mice, which received 6 weeks D-galactose injection.Results Compared to the control group,D-galactose-injected mice showed decreased levels of brain mitochondrial respiratory chain and ultrastructural path-ological changes of hippocampal mitochondria.Conclusion Brain mitochondrial degeneration may be involved in D-galactose -induced brain aging.关键词
D-半乳糖/线粒体/脑衰老Key words
D-galactose/mitochondria/brain aging分类
医药卫生引用本文复制引用
雷鸣,朱祖健..脑线粒体形态和呼吸链参与D-半乳糖诱导脑衰老的研究[J].实用临床医药杂志,2014,(13):4-6,3.基金项目
江苏建康职业学院科技发展基金 （）
