实用临床医药杂志Issue(15)：118-120,3.DOI:10.7619/jcmp.201415039
雾化吸入高剂量糖皮质激素对急性发作期儿童哮喘疗效的影响
Effect of aerosol inhalation of high-dose glucocorticoids on the efficacy of children with asthma at acute attack stage
摘要
Abstract
Objective To investigate the effect of aerosol inhalation of high-dose glucocor-ticoids on children with asthma at acute attack stage.Methods Ninety-three asthmatic children re-ceived in our hospital were randomly divided into treatment group (48 cases)and control group (45 cases).Both groups were given routine treatment like oxygen uptake.Besides,the treatment group was treated with aerosol inhalation of high-dose glucocorticoids and ipratropium bromide,while the control group was given glucocorticoid tablets and routine inhalation of ipratropium bromide.Before and 1 h after treatment,the heart rate (HR),respiratory rate (RR),forced expiratory volume in 1 second (FEV1),peak expiratory flow (PEF)and SpO2 of children in both groups were strictly monitored,clinical efficacies were compared and adverse reactions were observed.Results The overall response rate of treatment group (9 7 .9 % )was significantly higher than control group (82.2%)(P <0.05),with statistical significant difference.Compared with treatment before,the HR and RR slowed down markedly,FEV1 and PEF were improved and SpO2 increased obviously in both groups 1 h after treatment,in which the improved degrees of all the above indexes in treatment group were superior to control group ,with statistical significant differences (P < 0 .0 5 ,or P <0.01).The total incidence rate of adverse reactions was 12.5% (6 /48)and the total incidence rate of control group was 17.8% (8 /45),and there were no significant differences between 2 groups (P>0.05).Conclusion For the asthmatic children at acute attack stage,aerosol inhalation of high-dose glucocorticoids and ipratropium bromide can rapidly alleviate symptoms,ameliorate the lung function and elevate SpO2,with milder adverse reactions.关键词
糖皮质激素/雾化吸入/哮喘/急性发作Key words
glucocorticoids/aerosol inhalation/asthma/acute attack分类
医药卫生引用本文复制引用
魏晋琪,李一民..雾化吸入高剂量糖皮质激素对急性发作期儿童哮喘疗效的影响[J].实用临床医药杂志,2014,(15):118-120,3.基金项目
中国高校医学期刊临床专项资金 （）
