实用临床医药杂志Issue(16)：60-62,66,4.DOI:10.7619/jcmp.201416017
结直肠癌患者血清中高表达白介素22与FOLFOX 化疗抵抗的相关性
Correlation of high expression of interleukin 22 with FOLFOX chemoresistant status in colorectal cancer patients
吴庭玉 1刘云 1梁中林 1梅祖兵 1王光辉 1崔昂 1崔龙 1吴克瑾2
作者信息
- 1. 上海交通大学医学院附属新华医院 肛肠外科，上海，200092
- 2. 上海交通大学医学院附属新华医院 普通外科，上海，200092
- 折叠
摘要
Abstract
Objective To explore the correlation between IL-22 expression levels in serum and FOLFOX resistant status and to examine weather IL-22 could promote chemoresistance in colorec-tal cancer cells.Methods ELISA were preformed to detect IL-22 expression levels in 60 patients who received FOLFOX adjuvant chemotherapy after radical excision.The chemoresistant effect of IL-22 in colorectal cancer cells with treatment of chemotherapeutic drugs was investigated.Results IL-22 serum levels increased in chemoresistant patients compared with chemosensitive patients.In addi-tion,IL-22 could confer resistance to 5-FU and OXA of SW480 and SW620 cell lines.Conclusion Elevated serum IL-22 levels correlate with FOLFOX chemoresistant condition of colorectal cancer and may be an important factor for chemoresistance.关键词
白介素 22/结直肠癌/5 氟尿嘧啶/奥沙利铂Key words
interleukin 22/colorectal cancer/5-fluorouracil/oxaliplatin分类
医药卫生引用本文复制引用
吴庭玉,刘云,梁中林,梅祖兵,王光辉,崔昂,崔龙,吴克瑾..结直肠癌患者血清中高表达白介素22与FOLFOX 化疗抵抗的相关性[J].实用临床医药杂志,2014,(16):60-62,66,4.
