地氯雷他定对过敏性哮喘豚鼠模型肺泡灌洗液IL-4和 IL-13水平的影响OACSTPCD
Effects of desloratadine on the levels of IL-4 and IL-13 in bronchoalveolar lavage fluid of allergic asthmatic rats model
目的:研究地氯雷他定对过敏性哮喘豚鼠模型肺泡灌洗液 IL-4和 IL-13水平的影响。方法用卵蛋白造成过敏性哮喘豚鼠模型,观察地氯雷他定对过敏性哮喘豚鼠哮喘潜伏期、肺泡灌洗液 IL-4和 IL-13水平的影响。结果地氯雷他定能显著延长过敏性哮喘豚鼠哮喘潜伏期,明显降低肺泡灌洗液 IL-4和 IL-13水平。结论地氯雷他定能通过降低细胞因子 IL-4和 IL-13水平来延缓哮喘的发作,为其临床治疗哮喘提供实验依据。
Objective 5BTo study the effects of desloratadine on the level of IL-4 and IL-13 in bronchoalveolar lavage fluid of allergic asthmatic rat model.Methods The allergic asthmatic rat model was induced by ovalbumin.Then the effects of desloratadine on the latent period of asth-ma,the level of IL-4 and IL-13 in bronchoalveolar lavage fluid were observed.Results Deslorata-dine could extend the latent period of asthma,and decrease the level of IL-4 and IL-13 in bro…查看全部>>
张丽;白茹芹;柏立浩
江苏省南京市胸科医院,江苏 南京,210029江苏省南京市胸科医院,江苏 南京,210029江苏省南京市胸科医院,江苏 南京,210029
医药卫生
地氯雷他定过敏性哮喘豚鼠肺泡灌洗液IL-4IL-13
desloratadineallergic asthmaratsbronchoalveolar lavage fluidIL-4IL-13
《实用临床医药杂志》 2014 (16)
105-106,111,3
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