实用临床医药杂志Issue(16)：186-187,190,3.DOI:10.7619/jcmp.201416065
胰岛素生长因子-1及胰岛素因子结合蛋白-3在特发性矮小症诊断中的价值
Value of IGF-1 and IGFBP-3 in diagnosis of children with idiopathic short stature
黄丽娟 1羊柳 1徐星洋 1陈静秋 1陶岚1
作者信息
- 1. 江苏省靖江市人民医院 检验科，江苏 靖江，214500
- 折叠
摘要
Abstract
Objective To explore the value of serum insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3)in diagnosis of children with idiopathic short stature (ISS).Methods 36 ISS and 50 normal children were collected and divided into preadolescent group and adolescent group respectively.Serum IGF-1 and IGFBP-3 were detected by chemiluminescence analysis.Results There were significant positive correlations between age and the serum levels of IGF-1 and IGFBP-3(r =0.435,r =0.718,P <0.01)in both groups.The concentrations of IGF-1 and IGFBP-3 in adolescent group were significantly higher than those in preadolescent group,and the concentrations of IGF-1 and IGFBP-3 in ISS group were significantly lower than those in the control group (P <0.01).Conclusion The detections of IGF-I and IGFBP-3 have a great value in the diagnose,growth monitoring and the treatment with GH for children with ISS.关键词
特发性身体矮小/胰岛素生长因子-1/胰岛素结合蛋白-3/青春期/青春前期Key words
idiopathic short stature/insulin-like growth factor-1/insulin-like growth fac-tor binding protein-3/preadolescent period/adolescent period分类
医药卫生引用本文复制引用
黄丽娟,羊柳,徐星洋,陈静秋,陶岚..胰岛素生长因子-1及胰岛素因子结合蛋白-3在特发性矮小症诊断中的价值[J].实用临床医药杂志,2014,(16):186-187,190,3.
