实用临床医药杂志Issue(17)：22-24,3.DOI:10.7619/jcmp.201417007
高尔基体蛋白73和磷脂酰基醇蛋白聚糖-3联合测定在原发性肝癌早期诊断中的价值
Value of Golgi protein 73 combined with phosphatidyl alcohol proteoglycans-3 detection in early diagnosis of primary liver cancer
王延峰 1李南阳 1任雅玲 1薛秀斌 1李林臣 1曹蕾春 1贾儒渊 1于小平1
作者信息
- 1. 河北省张家口市第一医院，河北 张家口，075000
- 折叠
摘要
Abstract
Objective To explore the value of Golgi protein 73 (GP73 )combined with phosphatidyl alcohol proteoglycans-3 (GPC3 )detection in early diagnosis of primary liver cancer (PLC).Methods The serum GP73 and GPC3 levels were detected in 40 PLC patients,48 patients with liver cirrhosis,45 hepatitis patients and 44 healthy people by ELISA.Results Serum GP73 was (812.37±81.59)pg/mL and GPC3 was(89.27±12.38)ng/mL in PLC group,and GPC3, GP73 positive expression rate were 82.5%,87.5% respectively,which were significantly higher than the other 3 groups.GPC3 and GP73 levels,positive expression rate in liver cirrhosis patients and hepatitis patients were significantly higher than healthy control group.Sensitivity,specific de-grees and accuracy of GPC3 combined with GP73 detection were 92.5%,100% and 93.81%, which were significantly higher than those of GP73 ,GPC3 single test (P<0 .05 ).Conclusion GP73 combined with GPC3 detection can significantly improve the accuracy of PHC,which shows a high value in early diagnosis of PLC.关键词
高尔基体蛋白73/磷脂酰基醇蛋白聚糖-3/原发性肝癌/诊断价值Key words
Golgi protein 73/phosphatidyl alcohol proteoglycans-3/primary liver cancer/diagnostic value分类
医药卫生引用本文复制引用
王延峰,李南阳,任雅玲,薛秀斌,李林臣,曹蕾春,贾儒渊,于小平..高尔基体蛋白73和磷脂酰基醇蛋白聚糖-3联合测定在原发性肝癌早期诊断中的价值[J].实用临床医药杂志,2014,(17):22-24,3.
