实用临床医药杂志Issue(17)：73-75,79,4.DOI:10.7619/jcmp.201417021
子痫前期治疗前后血浆NT-proBNP和炎性细胞因子水平的变化
Changes of plasma NT-proBNP and inflammatory cytokines levels before and after treatment for preeclampsia
陈大立 1许咏梅 1彭兰 1杨永青 2柴利强1
作者信息
- 1. 南京医科大学附属苏州医院 苏州母子医疗保健中心 产科，江苏 苏州，215002
- 2. 南京医科大学附属苏州医院 苏州母子医疗保健中心 核医学科，江苏 苏州，215002
- 折叠
摘要
Abstract
Obj ective To explore changes of plasma NT-proBNP and inflamatory cytokines levels before and after treatment for preeclampsia.Methods The levels of NT-proBNP(with fluore-scent immunoassay)and infammatory cytokines(IL-6 ,hs-CRP and TNF-αwith high-sensitive en-zyme immunoassay and radio immunoassay)in plasma were detected in 93 patients with preeclamp-sia (including 45 cases of light pre-eclampsia and 48 cases of severe pre-eclampsia),and 42 normal people were collected and detected for contrastive analysis.Results Before treatment,the plasma NT-proBNP and inflammatory cytokines (IL-6 ,hs-CRP and TNF-α)levels in 93 patients with preeclampsia were significantly higher than those in 42 normal people (P<0 .0 1 ).The plasma NT-proBNP,IL-6,hs-CRP and TNF-αlevels increased with increasing degree of preeclampsia.After treatment,the levels of NT-proBNP,IL-6,hs-CRP and TNF-αin 45 patients with light pre-eclampsia reached to normal level (P>0 .05 ).Though the plasma IL-6 level reached to normal lev-el,the levels of NT-proBNP,hs-CRP and TNF-αin 48 patients with severe pre-eclampsia were sig-nificantly higher than those in 42 normal people (P<0 .05 ).Conclusion The plasma NT-proBNP and inflammatory cytokines participate in pathogenesis process of preeclampsia,and these two indi-cators are effective monitoring index for the early treatment of preeclampsia.关键词
子痫前期/N氨基末端脑利钠肽前体/炎性细胞因子/有效指标Key words
preeclampsia/N-ternimal pro-B-type natriuretic peptide/inflammatory cy-tokines/effective index分类
医药卫生引用本文复制引用
陈大立,许咏梅,彭兰,杨永青,柴利强..子痫前期治疗前后血浆NT-proBNP和炎性细胞因子水平的变化[J].实用临床医药杂志,2014,(17):73-75,79,4.
