军事医学Issue(4)：241-244,4.DOI:10.7644/j.issn.1674-9960.2014.04.001
健康青年男性急进高原肺动脉高压危险因素分析
Analysis of risk factors of pulmonary hypertension in healthy Chinese young males after rapid ascent to high altitude
摘要
Abstract
Objective To investigate the risk factors of pulmonary hypertension (PH) after rapid ascent to high altitude in healthy young Chinese men .Methods A total of 552 non high altitude natives ( healthy young Chinese men ) were recruited in the study between June to August in 2012.The subjects were delivered to high altitude (3700 m) in 2 h by plane from low altitude (450 m).Demographic data including smoking , alcohol consumption , high altitude exposure histo-ry, body mass index (BMI) and age were collected within 24 h after arrival at 3700 m.Furthermore, the oxygen saturation ( SaO2 ) , blood pressure , heart rate , pulmonary artery systolic pressure were measured using the echocardiography system . Analysis of risk factors of PH was performed by logistic regressions .Results The incidence of PH was 23.10%.SaO2 was significantly lower in the higher-pulmonary artery systolic pressure group (higher-PASP)[(86.10 ±3.34)%] than that in the normal-PASP group [(89.09 ±2.65)%, P<0.01].Smoking, alcohol consumption, high altitude exposure history, BMI, age, systolic blood pressure , diastolic blood pressure , heart rate were not significantly different between the two groups mentioned above .Logistic regressions revealed that lower SaO 2 (OR:0.711,95% CI:0.647-0.782, P<0.01) was an independent risks factor of PH .Conclusion Low SaO2 is an independent risk factor of PH upon rapid arrival at 3700 m in healthy young Chinese men .However, smoking, alcohol consumption , high altitude exposure history , BMI, age, blood pressure and heart rate are not risk of PH .These observations will provide valuable clues to theoretical studies on PH and prevention of PH .关键词
肺动脉高压/危险因素/青年男性/高原Key words
pulmonary hypertension/risk factors/young men/high altitude分类
医药卫生引用本文复制引用
李相俊,武晓静,覃军,杨特,李双菲,刘曦,黄岚..健康青年男性急进高原肺动脉高压危险因素分析[J].军事医学,2014,(4):241-244,4.基金项目
国家卫计委卫生行业科研专项基金资助项目（201002012）；国家自然科学基金资助项目 （）
