军事医学Issue(11)：890-892,3.DOI:10.7644/j.issn.1674-9960.2014.11.012
胰岛素治疗对阿尔茨海默病合并2型糖尿病患者认知功能的影响
Effect of insulin treatment on cognitive function of patients with Alzheimer′s disease and type 2 diabetes mellitus
赵翠 1李伟 1王璐 1王国玉 1曹俊杰 1王淼1
作者信息
- 1. 承德医学院附属医院，河北承德 067000
- 折叠
摘要
Abstract
Objective To investigate the therapeutic effect of insulin combined with oral hypoglycemic agents on cognitive function of patients with Alzheimer′s disease(AD) and diabetes mellitus(DM).Methods We retrospectively reviewed 135 cases of AD patients with type2 DM(T2DM) admitted to our hospital between March 2011 and March 2013. According to drug use , they were randomly divided into two groups , oral hypoglycemic drug group ( group A, 65 cases ) and insulin combined with oral hypoglycemic drug group (group B,70 cases).After 12 months of follow-up, the Mini Mental State Examination (MMSE) score by Folstein et al and Clinical Global Impression Scale (CGI) were used to assess their cognitive function .Results After 12 months of treatment , the MMSE score decreased significantly in group A ( P=0.000), but not in group B(P=0.281).Also, CGI-C scores showed significant deterioration for all domains after 12 months in group A vs group B(P=0.001).Conclusion Insulin therapy can effectively slow down the decline of cognitive function in patients with AD .关键词
阿尔茨海默病/糖尿病,2型/胰岛素/认知损害Key words
Alzheimer′s disease/diabetes mellitus , type 2/insulin/cognitive impairment分类
医药卫生引用本文复制引用
赵翠,李伟,王璐,王国玉,曹俊杰,王淼..胰岛素治疗对阿尔茨海默病合并2型糖尿病患者认知功能的影响[J].军事医学,2014,(11):890-892,3.
