军事医学Issue(5)：398-402,5.DOI:10.7644/j.issn.1674-9960.2015.05.019
整合因子复合体研究进展
Integrator complex and its research progress
思兰兰 1张红星 2周钢桥1
作者信息
- 1. 广西医科大学，南宁 530021
- 2. 军事医学科学院放射与辐射医学研究所，北京蛋白质组研究中心，蛋白质组学国家重点实验室，北京 100850
- 折叠
摘要
Abstract
The integrator complex is multifunctional and contains at least 12 evolutionarily conserved subunits in hu-mans.It interacts with the C-terminal tail of the largest subunit of RNA-polymeraseⅡ ( RNAPⅡ) to promote 3′-end pro-cessing of small nuclear RNA (snRNA) U1/U2.It also interacts with RNAPⅡ, NELF and Spt5 to regulate NELF-mediated RNAPⅡpause/release and processivity at coding genes .Recently, the integrator complex is also reported to be involved in DNA damage response , dynein recruitment to the nuclear envelope , integrity of Cajal bodies , adipose differentiation , hem-atopoiesis , ciliogenesis , tumorigenesis and generation of viral microRNAs .This review discusses related research progress in the integrator complex .关键词
整合因子复合体/RNA聚合酶Ⅱ/小核RNA/mRNA转录Key words
integrator complex/RNA polymeraseⅡ/snRNA/mRNA transcription分类
生物科学引用本文复制引用
思兰兰,张红星,周钢桥..整合因子复合体研究进展[J].军事医学,2015,(5):398-402,5.
