解放军医学院学报Issue(3)：208-211,242,5.DOI:10.3969/j.issn.2095-5227.2015.03.003
功能性消化不良患者症状与病理生理改变的相关性
Correlation between symptoms and pathophysiological mechanism of patients with functional dyspepsia
邸岩 1夏志伟 1葛颖 1王琨 1徐志洁 1段丽萍1
作者信息
- 1. 北京大学第三医院 消化科，北京 100191
- 折叠
摘要
Abstract
Objective To analyze the association between dominant symptoms in different subtypes of functional dyspepsia (FD) and Helicobacter pylori (Hp) infection.Methods Patients matched with FD criterion of RomeⅢwere enrolled in the outpatient service. After investigating the dominant symptoms, they were divided into three subtypes: postprandial distress syndrome (PDS), epigastric pain syndrome (EPS) and overlapped (OL) group. Main symptoms and degree of their severity in patients were evaluated by 5-H gastric emptying test and drinking load test. The differences between Hp infection, gastric emptying and visceral perceptive threshold of different subtypes of patients, and the association between single symptom and pathophysiologic changes mentioned above were analyzed. ResultsThere were 108 patients enrolled in this study. The Hp infection rate in EPS (35.7%, 10/28) was higher than that in PDS (16%, 8/50,P=0.038) and OL (10%, 3/30,P=0.021). Patients with abdominal distension showed low Hp infection rate. The PDS patients showed slowly gastric emptying, but patients suffered with early satiety showed rapid gastric emptying. The maximum tolerance value of patients suffered from postprandial fullness and belching decreased.Conclusion Different subtypes of FD patients have different Hp infection rate, while the Hp infection is not associated with symptoms and pathophysiological changes. Gastric motility and sensation changes are closely related to some special symptoms, and dominant symptoms of patients should be paid attention to during treatment.关键词
功能性消化不良/胃排空功能/饮水试验/幽门螺杆菌Key words
functional dyspepsia/gastric emptying/drinking water load test/helicobacter pylori分类
医药卫生引用本文复制引用
邸岩,夏志伟,葛颖,王琨,徐志洁,段丽萍..功能性消化不良患者症状与病理生理改变的相关性[J].解放军医学院学报,2015,(3):208-211,242,5.
