解放军医学院学报Issue(4)：333-336,4.DOI:10.3969/j.issn.2095-5227.2015.04.009
抗凝血杀鼠剂中毒6例报道并文献复习
Anticoagulant rodenticide poisoning：A report of 6 cases and literature review
摘要
Abstract
Objective To analyze the mechanism, clinical characteristics, diagnoses and treatments of anticoagulant rodenticides poisoning.Methods Six cases diagnosed with anticoagulant rodenticides poisoning in our department since 2012 were enrolled in this study and its related literatures were reviewed.Results Poisoning was characterized by hematuria, bleeding of oral and nasal cavities in 6 patients. Of the 6 cases, 3 patients presented with hematuria as primary clinical manifestation and one of them was accompanied by bleeding of oral and nasal cavities; 2 were accompanied by oral mucosal bleeding and 1 by skin petechiae or ecchymoses; 1 without bleeding symptom. The white blood count (WBC) elevated mildly in 3 patients, hemoglobin level decreased in 5 cases; prothrombin time, activated partial prothrombin time and thrombin time were prolonged and activity of thrombinogen reduced in 5 patients. Coagulation factorⅡ Ⅶ,Ⅸ,Ⅹdecreased. Hemorrhage was effective after supplementary of vitamin K1 or fresh frozen plasma (or prothrombin complex).ConclusionPrimary manifestation being hemorrhage of multiple sites should be taken into account the possibility of anticoagulant rodenticides poisoning, which is mainly treated by supplementary of vitamin K1.关键词
抗凝血杀鼠剂/农药中毒/治疗Key words
anticoagulantrodenticides/peaticides poisoning/therapy分类
医药卫生引用本文复制引用
李蓓,冯聪,周璇,宋晓莉,黎檀实..抗凝血杀鼠剂中毒6例报道并文献复习[J].解放军医学院学报,2015,(4):333-336,4.基金项目
“十二五”农村领域国家科技计划课题(2012BAJ18B02-03) Supported by the "Twelfth Five Year Plan" National Science and Technology Plan Project of Rural Areas (2012BAJ18B02-03) （2012BAJ18B02-03）
