解放军医学院学报Issue(4)：351-354,4.DOI:10.3969/j.issn.2095-5227.2015.04.014
晚期胃癌患者其肿瘤相关性贫血与预后的关系
Relationship between cancer related anemia and prognosis in patients with advanced gastric cancer
陈杨 1王艳荣 1张权 1石燕 1陈丽 1戴广海1
作者信息
- 1. 解放军总医院 肿瘤内二科，北京 100853
- 折叠
摘要
Abstract
Objective To assess the relationship between cancer related anemia (CRA) and prognosis in patients with advanced gastric cancer who were treated by Epirubicin Oxaliplatin and Xeloda as first-line chemotherapy.Methods Clinical data about 58 patients diagnosed with advanced gastric cancer who underwent first-line chemotherapy of EOX regimen at least 2 cycles in our hospital from 2012 to 2013 were retrospectively analyzed. According to the level of hemoglobin before and during treatment period, the patients were divided into two groups: anemia group (A1) and the absent group (A0).The relationship between CRA and clinical outcome of these two groups were analyzed.ResultsThe median PFS and OS in group A1 were significantly lower than group A0 (5.3 vs 7.2 m,P=0.032; 13.6vs17.1 m,P=0.027). The multivariate Cox analysis showed that the adjusted hazard ratio (HR) of PFS in anemia group was 25% lower than group A0 (HR 0.75, 95% CI: 0.413-0.914, P=0.018). The mortality risk of OS was 26% lower than group A0 (HR 0.74, 95%CI: 0.452-0.921, P=0.032).Conclusion The anemia patients are likely to have a shorter PFS and OS compared with normal patients. The cancer related anemia is an independent prognostic factor. Prospective trials are required to validate those findings.关键词
胃癌/肿瘤相关性贫血/预后Key words
gastric cancer/cancer related anemia/prognosis分类
医药卫生引用本文复制引用
陈杨,王艳荣,张权,石燕,陈丽,戴广海..晚期胃癌患者其肿瘤相关性贫血与预后的关系[J].解放军医学院学报,2015,(4):351-354,4.
