解放军医学院学报Issue(5)：444-446,525,4.DOI:10.3969/j.issn.2095-5227.2015.05.010
125I粒子联合高强度聚焦超声治疗肝癌门静脉癌栓的疗效评价
Therapeutic effect of hepatocellular carcinoma portal vein tumor thrombus treated by125I particles implantation combined with high intensity focused ultrasound therapy
侯雅昕 1于晓玲 1韩治宇 1刘方义 1赵文鹏 1李华蓉1
作者信息
- 1. 解放军总医院 介入超声科，北京 100853
- 折叠
摘要
Abstract
Objective To evaluate the therapeutic effect of hepatocellular carcinoma (HCC) portal vein tumor thrombus (PVTT) treated by125I particles implantation combined with high intensity focused ultrasound (HIFU) therapy. Methods Nineteen patients with hepatocellular carcinoma portal vein tumor thrombus in different grading who underwent125I particles implantation combined with HIFU therapy in our hospital from March 2011 to October 2013 were enrolled in our study. The125I radioactive dose was 80 - 120 Gy, single particle radioactive dose was 0.5 mCi; HIFU: the frequency was 0.85 MHz, the total treatment time was 33 - 70 min, and the irradiation power was at an average of 300 - 400 w. 1 - 30 months of follow-up evaluation was made concerning the curative effect and adverse reaction, the tumor emboli size changes before and after treatment, postoperative complications and survival rate of the patients.Results All patients had undergone complete treatment, there was no postoperative bleeding, cancer plug and severe complications such as acute liver failure. After 1 month's review, all tumor embolus shrank to different extent. Following-up was done 1 to 30 months with the survival time of 3 - 26 months. 1- and 2- year survival rate were 47.4% (n=9) and 21.1% (n=4), and the average survival period was (11.6±3) months, levelⅠ,Ⅱ,Ⅲ median survival were 13.5, 7, 4 months, respectively.Conclusion The local curative effect of125I implantation combined with high intensity focused ultrasound in treatment ofhepatocellular carcinoma with portal vein tumor thrombus is obvious, with small trauma and low complication rate. It is a simple, safe and effective treatment.关键词
肝细胞性肝癌/门静脉癌栓/125I粒子植入治疗/高强度聚焦超声Key words
hepatocellular carcinoma/portal vein tumor thrombus/125I particles brachytherapy/high intensity focused ultrasound分类
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侯雅昕,于晓玲,韩治宇,刘方义,赵文鹏,李华蓉..125I粒子联合高强度聚焦超声治疗肝癌门静脉癌栓的疗效评价[J].解放军医学院学报,2015,(5):444-446,525,4.
