解放军医学院学报Issue(7)：762-765,4.DOI:10.3969/j.issn.2095-5227.2015.07.032
PD-1/PD-L1信号通路在肿瘤免疫逃逸中的作用及临床意义
Advances in PD-1/PD-L1 signaling pathway in tumor immune evasion and its clinical significance
摘要
Abstract
With the deep understanding of tumor immune microenvironment, people find that immune evasion of tumor cells is the main factor of tumor progression. PD-1/PD-L1 signal pathway is a negative immune costimulatory molecule found in recent years which plays an important role in tumor immune evasion. This review briefly summarizes the mechanism of PD-1/PD-L1 signal pathway in tumor immune evasion and research progress of their antibodies in the treatment of tumor, which may provide new ideas and methods for tumor immunotherapy.关键词
程序性死亡分子1/PD-1配体/肿瘤/肿瘤免疫Key words
programmed death 1/programmed death 1 ligand/neoplasms/tumor immunity分类
医药卫生引用本文复制引用
李瑛,范忠义,尤文叶,杨俊兰,焦顺昌..PD-1/PD-L1信号通路在肿瘤免疫逃逸中的作用及临床意义[J].解放军医学院学报,2015,(7):762-765,4.基金项目
总后卫生部保健项目(BWS11J010) （BWS11J010）
