检验医学与临床Issue(9)：1169-1170,2.DOI:10.3969/j.issn.1672-9455.2014.09.007
多层螺旋 CT 灌注成像在脑胶质瘤分级中的价值与微血管密度的相关性研究
Application value of multi-slice spiral CT perfusion imaging in brain gliomas and its relation with microvessel density
摘要
Abstract
Objective To study the value of multi-slice spiral CT (MSCT ) perfusion imaging in grading of brain glioma(BG) and its correlation with microvessel density (MVD) .Methods A total of 89 BG patients ,treated in this hospital from March 2010 to March 2013 ,were enrolled and divided into high grade group and low grade group , according to the grading levels .MSCT parameters and MVD ,vascular endothelial growth factor(VEGF) levels were compared ,and the correlation between relative cerebral blood flow (rCBV) and MVD ,VEGF were analyzed .Results Levels of cerebral blood flow (CBF) ,rCBF ,cerebral blood volume(CBV) ,relative CBV(rCBV) of high grade group were significantly higher than low grade group (P< 0 .05) .The positive rate of VEGF in high grade group was 89 .13% (41/46) ,higher than the 55 .81% (24/43) of low grade group(P<0 .05) .Level of MVD in high grade group was 70 .76 ± 8 .85 ,significantly higher than the 37 .75 ± 5 .65 of low grade group(P<0 .05) .rCBV level was positive-ly correlated with MVD and VEGF expression level (r= 0 .610 and r= 0 .631 ,P< 0 .05) .Conclusion rCBV level could be positively correlated with MVD and VEGF expression level in patients wit BG .MSCT could provide fine im-aging evidence for the grading of BG .关键词
多层螺旋CT灌注成像/脑胶质瘤分级/微血管密度/相关性Key words
multi-slice spiral CT perfusion imaging/brain gliomas/microvessel density/correlation引用本文复制引用
洪建斌,许乃滔,侯志雄..多层螺旋 CT 灌注成像在脑胶质瘤分级中的价值与微血管密度的相关性研究[J].检验医学与临床,2014,(9):1169-1170,2.基金项目
中国高校医学期刊临床专项资金项目（112210425）。 （）
