摘要
Abstract
Objective To observe the curative effect of autologous peripheral blood stem cell transplantation in the treatment of hepatitis B cirrhosis .Methods A total of 50 patients with hepatitis B virus related decompensated cirrhosis ,including 26 cases receiving autologous peripheral blood stem cell transplantation treatment and general treatment (treatment group) ,and 24 receiving general treatment (control group) .After treatment ,alanine amin-otransferase (ALT ) ,aspartate aminotransferase (AST ) ,albumin (ALB) ,total bilirubin (TBIL) ,prothrombin activity (PTA) level and Child-Pugh score were re -detected ,and adverse reactions and clinical symptoms were observed .Re-sults At the fourth week after treatment ,levels of ALT ,AST ,ALB and PTA were significantly improved ,compared with control group (P<0 .05) ,but improvement of TBIL were without significant difference .After 4 weeks of treat-ment ,clinical symptoms in treatment gorup were significantly improved than control group ,including fatigue im-proved in 20 cases (76 .9% ) ,appetite improved in 16 cases (61 .5% ) ,ascites decreased or disappeared completely in 22 cases (84 .6% ) ,and no serious complication was found .Conclusion Autologous peripheral blood stem cell trans-plantation for treatment of hepatitis B cirrhosis could be with recent safety and effectiveness ,and could improve the liver function of patients .关键词
肝硬化/外周血干细胞/移植Key words
liver cirrhosis/peripheral blood stem cell/transplantation
