检验医学与临床Issue(10)：1356-1357,2.DOI:10.3969/j.issn.1672-9455.2014.10.023
载脂蛋白E在系统性红斑狼疮患者中的表达及其临床意义
Expression and clinical significance of apolipoprotein E in patients with systemic lupus erythematosus
安和兵 1边江 2贾慧宇3
作者信息
- 1. 河北北方学院附属第二医院检验科，河北张家口 075100
- 2. 石家庄医学高等专科学校，石家庄 050000
- 3. 河北北方学院附属第二医院检验科，河北张家口 075100
- 折叠
摘要
Abstract
Objective To explore the expression level and clinical significance of apolipoprotein E (Apo E) in patients with systemic lupus erythematosus (SLE) .Methods From Aug .2012 to May 2013 ,47 SLE patients and 40 healthy controls in the Second Affiliated Hospital of Hebei North University were enrolled and detected for serum ApoE level by using enzyme linked immunosorbent assay (ELISA ) .Patients were divided into different groups ac-cording to clinical indicators ,and data were statistically analyzed .Results Compared with healthy controls ,ApoE level of SLE patients were increased [(15 .2 ± 4 .4)pg/mL vs .(8 .6 ± 3 .3)pg/mL ,P<0 .05)] ,and activity SLE pa-tients higher more pronounced than inactivity [(18 .3 ± 6 .1)pg/mL vs .(14 .2 ± 5 .7)pg/mL ,P<0 .05] .ApoE levels of patients with or without nephritis were higher than healthy controls (P<0 .05) ,but no statistically different be-tween the two patient groups (P> 0 .05) .ApoE of anti-dsDNA antibody positive SLE patients were marked in-creased ,compared with anti-dsDNA antibody negative patients [(17 .9 ± 5 .8)pg/mL vs .(13 .9 ± 4 .7)pg/mL ,P<0 .05)] .Conclusion ApoE could be used as an effective indicator of disease activity in patients with SLE ,and provide certain theoretical basis for immunotherapy of disease .关键词
系统性红斑狼疮/载脂蛋白E/狼疮性肾炎/抗核抗体Key words
systemic lupus erythematosus/apolipoprotein E/lupus nephritis/antinuclear antibodies引用本文复制引用
安和兵,边江,贾慧宇..载脂蛋白E在系统性红斑狼疮患者中的表达及其临床意义[J].检验医学与临床,2014,(10):1356-1357,2.
