检验医学与临床Issue(12)：1613-1614,1617,3.DOI:10.3969/j.issn.1672-9455.2014.12.009
超广谱β-内酰胺酶大肠杆菌院内感染分布及耐药性研究
Research for distribution and resistance of ESBLs
摘要
Abstract
Objective To understand status of the ultra broad spectrum beta lactamase (ESBLs) of MCH ,and analyze its drug resistance ,and to provide guidance to clinical for reasonable use antibiotics .Methods By the method of K-B ,87 strains of e .coli were tested for their their clinical distribution and drug sensitive .Strains of antibiotic sus-ceptibility was analyzed by WHONET5 .4 .Results 41 strains of producing extended-spectrumβ-lactamases were de-tected in the 87 strains of e .coli ,47 .26% (41/87);specimens mainly come from urine ,wound secretion(including lo-chia) ,sputum and blood ;Susceptibility testing shows sensitive rate of imipenem and meropenem were 100% ,Pip-eracillin /tazobactam was 90 .25% ,amikacin was 82 .93% ,Nitrofurantoin was 73 .16% ,others are less than 50% . Conclusion Positive rate of beta lactamase (ESBLs) from the ultra broad spectrum of MCH is in a relatively high level ,it has different drug resistance to 16 kinds of drug except imipenem and meropenem ,the use and classification management of antimicrobial drugs should be Strengthened in hospital .In order to reduce the incidence of nosocomial infection .Clinicians should combine with strain susceptibility testing to choose the most suitable antimicrobial .关键词
超广谱β-内酰胺酶/大肠杆菌/耐药性/妇幼保健院Key words
extended-spectyumβ-lactamases/escherichia coli/drug resistance/MCH引用本文复制引用
杨小影,宋惠萍,杨萍芝,吴洪秋..超广谱β-内酰胺酶大肠杆菌院内感染分布及耐药性研究[J].检验医学与临床,2014,(12):1613-1614,1617,3.基金项目
广东省珠海市科工贸信局科研课题（2013281）。 （）
