检验医学与临床Issue(14)：1895-1897,3.DOI:10.3969/j.issn.1672-9455.2014.14.003
瑞格列奈联合二甲双胍治疗2型糖尿病临床疗效观察
Clinical curative effect of repaglinide combined with metformin in the treatment of type 2 diabetes
摘要
Abstract
Objective To study clinical effect of repaglinide combined with metformin in the treatment of type 2 diabetes .Methods A total of 400 patients with type 2 diabetic were divided into observation group ,treated with repaglinide combined with metformin ,and control group ,treated with metformin .Levels of blood sugar ,cardiac func-tion ,and lower limb nerve and motor function were observed .Results Early diastolic peak velocity (E peak) ,ratio of E and late diastolic peak velocity (A peak ,E/A) ,left ventricular ejection fraction (LVEF) ,left ventricular end dias-tolic diameter (LVEDD) ,walking distance ,walking speed ,motor nerve conduction velocity (MCV ) ,sensory nerves conduction velocity (SCV) were significantly higher than control group ,but A peak ,lower extremity motor nerve la-tency (LAT) were significantly lower .E peak ,E/A value ,LVEF ,LVEDD ,walking distance ,walking speed ,MCV and SCV were negatively correlated with glycosylated hemoglobin content ,and A peak and LAT were positively cor-related with glycosylated hemoglobin level .Conclusion Repaglinide combined with metformin could be efficient for controlling blood glucose level in patients with type 2 diabetic ,which could also improve cardiac function ,and lower limb nerve and motor function .关键词
2型糖尿病/胰岛素/增敏剂/促分泌剂Key words
type 2 diabetes/insulin/sensitizer/secretagogue引用本文复制引用
李玲,任伶俐,刘琳,周广举,彭乙华,李娜,蔡燕..瑞格列奈联合二甲双胍治疗2型糖尿病临床疗效观察[J].检验医学与临床,2014,(14):1895-1897,3.基金项目
四川省卫生厅基金资助项目（100165）。 （）
