检验医学与临床Issue(17)：2354-2356,3.DOI:10.3969/j.issn.1672-9455.2014.17.005
MMP-11在食管鳞状细胞癌组织中的表达水平及临床意义分析
Expression and clinical significance of MMP-11 protein in esophageal squamous cell carcinoma
摘要
Abstract
Objective To explore the correlation between matrix metalloproteinases-11(MMP-11) and esopha-geal squamous cell carcinoma(ESCC) .Methods Expression of MMP-11 protein was detected by immunohistochem-istry in 36 cases of ESCC tissues and tumor-adjacent tissues ,and 9 cases of normal esophageal tissues .Results Posi-tive expression rate of MMP-11 in ESCC tissues was higher than tumor-adjacent tissues and normal tissues ,which were 69 .4% (25/36) ,25 .0% (9/36) and 22 .2% (2/9) respectively(P<0 .05) .Positive expression rates of MMP-11 protein in patients at T1 -T2 stage ,Ⅰ - Ⅱ stage and with nodal metastases were lower than patients at T3 -T4 stage ,Ⅲ - Ⅳ stage and without nodal metastases respectively (P<0 .05) .No correlations were found between MMP-11 protein expression levels and age ,gender ,tumor location ,tumor diameter and degree of differentiation(P>0 .05) . Conclusion Up-regulation of MMP-11 expression level might be involved in the development of ESCC ,which might play a promoting role in the invasion and metastasis of ESCC .关键词
食管鳞状细胞癌/基质金属蛋白酶-11/免疫组织化学Key words
esophageal squamous cell carcinoma/matrix metalloproteinases-11/immunohistochemistry引用本文复制引用
张晓伟,唐启明,刘春华,肖锋,胡建功..MMP-11在食管鳞状细胞癌组织中的表达水平及临床意义分析[J].检验医学与临床,2014,(17):2354-2356,3.基金项目
山东省卫生厅资助项目（2013WS0323）。 （）
