检验医学与临床Issue(18)：2553-2554,2556,3.DOI:10.3969/j.issn.1672-9455.2014.18.023
缺氧诱导因子-1α和基质蛋白酶-9在鼻息肉嗜酸性粒细胞浸润过程中的作用
Effect of HIF-1αand MMP-9 in the infiltration of eosinophile granulocyte in nasalpolyps
佘腊枝 1鲁海涛 1谢琼1
作者信息
- 1. 湖北省荆州市中心医院耳鼻喉科 434020
- 折叠
摘要
Abstract
Objective To investigate the expressions of hypoxia induced factor-lα(HIF-1α) and matrix metal-loproteinase-9 (MMP-9) in nasalpolyps tissues and their relationships with the infiltration of eosinophilic granulocyte (EOS) in nasalpolyps tissues .Methods During Oct .2010 and Dec .2012 ,nasal polyp tissues were collected from 31 patients with nasalpolyps treated with nasal endoscopy (observation group) ,and inferior turbinate mucosa were col-lected from 11 patients with chronic hypertrophic rhinitis treated with partial inferior turbinectomy (control group) . mRNA expression levels of HIF-1αand MMP-9 in tissue samples of the two groups were assayed .Amounts of cells and blood vessels positive with HIF-1α and MMP-9 ,and infiltration amounts of EOS were also detected .Results mRNA expression levels of HIF-1αand MMP-9 in observation group were higher than control group (P<0 .05) .The amounts of cells and blood vessels positive with HIF-1αand MMP-9 and the infiltration amounts of EOS in observa-tion group were also higher than control group (P<0 .05) .In observation group ,the amounts of cells positive with HIF-1αand MMP-9 were positively correlated with the infiltration amounts of EOS (with correlation coefficients of 0 .56 and 0 .88 respectively ,P<0 .05) .Conclusion Expression levels of HIF-1αand MMP-9 could be high in nasal-polyps tissues ,which might be closely related with the pathogenesis of nasalpolyps .关键词
鼻息肉/缺氧诱导因子-1α/基质金属蛋白酶-9/嗜酸性粒细胞Key words
nasalpolyps/hypoxia induced factor-lα/matrix metalloproteinase-9/eosinophilic granulocyte引用本文复制引用
佘腊枝,鲁海涛,谢琼..缺氧诱导因子-1α和基质蛋白酶-9在鼻息肉嗜酸性粒细胞浸润过程中的作用[J].检验医学与临床,2014,(18):2553-2554,2556,3.
