检验医学与临床Issue(19)：2651-2653,3.DOI:10.3969/j.issn.1672-9455.2014.19.002
三阴性乳腺癌新辅助化疗前Ki-67表达与病理完全反应相关性的Meta分析
Relationship between the expression of Ki-67 and pathological complete response in triple-negative breast cancer before neoadjuvant chemotherapy:A Meta-analysis
摘要
Abstract
Objective To systematically evaluate the relationship between the expression of Ki-67 and patho-logical complete response in triple-negative breast cancer (TNBC)before the neoadjuvant chemotherapy .Methods Articles about the association between the expression of Ki-67 before the neoadjuvant chemotherapy and pathological complete response were retrieved from PubMed ,CNKI and Wanfang database .The risk ratio (RR) was used to eval-uate the relationship between the expression of Ki-67 before the neoadjuvant chemotherapy and pathological complete response in TNBC .Rev-Man 5 .2 software was applied to perform the meta-analysis .Results A total of 10 articles (3 articles in Chinese and 7 articles in English) were eligible for the meta-analysis .There were 649 patients with triple-negative breast cancer .Thus ,the fix model was applied to calculate the pooled RR (RR= 4 .04 ,95% CI= 2 .66 -6 .15 ,P<0 .01) .Conclusion It was about 4 times for the rate of pathological complete response in TNBC with the high-expression of Ki-67 compared with the low-expression Ki-67 before the neoadjuvant chemotherapy .关键词
三阴性乳腺癌/新辅助化疗/Ki-67/病理完全缓解/M eta分析Key words
triple-negative breast cancer/neoadjuvant chemotherapy/Ki-67/pathological complete re-sponse/Meta-analysis引用本文复制引用
张莉,龙行华..三阴性乳腺癌新辅助化疗前Ki-67表达与病理完全反应相关性的Meta分析[J].检验医学与临床,2014,(19):2651-2653,3.基金项目
国家自然科学基金资助项目（30873044，81272372），教育部留学回国人员科研启动基金资助项目（教外司留［2011］1139号）。 （）
