检验医学与临床Issue(19)：2658-2659,2662,3.DOI:10.3969/j.issn.1672-9455.2014.19.005
3种尿液指标检测在造影剂肾病中的诊断价值
Value about combined detection of cystatin C,n-acety-l B-D-glucosaminidase and urine microalbumin in diagnosis of con-trast induced nephropathy
摘要
Abstract
Objective To evaluate the clinical significance of combined detection of Cystatin C (Cys C) ,n-ace-tyl-β-d-glucosaminidase (NAG ) and microalbumin (mALB ) in early diagnosis of contrast induced nephropathy (CIN) .Methods A total of 91 patients with angiography enrolled in this study were divided into CIN group and non-CIN group according to appearance of CIN after angiography 48 h .Cys C ,NAG and mALB were measured before an-giography ,after angiography 12 h ,24 h ,48 h respectively .Results The prevalence of CIN was 13 .2% in all patients registered in this study .The levels of Cys C and NAG in CIN group significantly increased after angiography 12 h , and reached the peak after 24 h and began to decrease after 48 h ,but all were obviously higher than those before in-jection contrast and those in the non-CIN group(P<0 .05) .The level of mALB after contrast injection 24 h began to increased and reached the peak after 48 h in CIN group ,and it were obviously higher than that before injection con-trast and that in the non-CIN group(P<0 .05) .The sensitivity and specificity of combined detection of these 3 inde-xes improved significantly compared with single index detection .Conclusion Combined detection of Cys C ,NAG and mALB play important role in the early diagnosis of CIN .关键词
胱抑素C/尿N-乙酰-β氨基葡萄糖苷酶/尿微量清蛋白/造影剂肾病Key words
cystatin C/n-acetyl-β-d-glucosaminidase/microalbumin/contrast induced nephropathy引用本文复制引用
王海滨,石新慧,张静..3种尿液指标检测在造影剂肾病中的诊断价值[J].检验医学与临床,2014,(19):2658-2659,2662,3.基金项目
国家重大科学仪器设备开发专项基金（2013YQ1904670703）。 （）
