检验医学与临床Issue(19)：2663-2664,2667,3.DOI:10.3969/j.issn.1672-9455.2014.19.007
血清视黄醇结合蛋白和胱抑素C在2型糖尿病早期肾功能损害中的应用
Application value of serum retinol binding protein and cystatin C on early renal damage of type 2 diabetic nephropathy
摘要
Abstract
Objective To evaluate the diagnostic value of the serum retinol binding protein (RBP) and cystatin C (Cys C)on the early stage of type 2 diabetic nephropathy by roc curve .Methods According to the ratio of urinary albumin and urinary creatinine ,155 patients with type 2 diabetes were divided into simple diabetic mellitus (SDM ) group ,early stageof diabeticnephropathy(EDN)group ,andclinicalstageof diabeticnephropathy(CDN)group ,while healthy persons were recruited randomly at the same period as control group .The level of serum RBP and Cys C were detected by colloidal gold immunoenhancement method and immunoturbidimetry .The diagnostic value of RBP and Cys C in the early stage of type 2 diabetic nephropathy was analyzed by ROC curve .Results With the development of the disease ,the level of serum RBP and Cys C increased ,RBP and Cys C in CDN group were significant higher than those in the SDM group and the NC group(P<0 .01) ,while had a correlation with the rario of urinary albumin and creatinine .The area under the ROC curve of RBP and Cys C in serum were 0 .770 ,0 .868;the cutoff value were 40 .95 mmol/L ,1 .055 mmol/L ;the sensitivity were 81 .0% ,93 .7% ;the specificity were 95 .2% ,78 .1% .Conclusion RBP and Cys C were good markers in detecting early renal damage ,the diagnostic value of Cys C was superior to RBP ,and combined detection of the two methods will greatly improve the efficiency of diagnosing for early diabetic kidney inju-ry .关键词
受试者特征工作曲线/血清视黄醇结合蛋白/血清胱抑素C/糖尿病肾病Key words
ROC curve/retinol binding protein/Serum cystatin C/diabetic nephropathy引用本文复制引用
李光荣,刘靳波,明兰..血清视黄醇结合蛋白和胱抑素C在2型糖尿病早期肾功能损害中的应用[J].检验医学与临床,2014,(19):2663-2664,2667,3.基金项目
四川省卫生厅科研课题（110359）；泸州市科技计划项目（2011-S-38（2／4））；泸州医学院青年基金课题（泸医院［2010］108号）。 （）
