检验医学与临床Issue(21)：2960-2962,3.DOI:10.3969/j.issn.1672-9455.2014.21.007
精神分裂症患者白细胞介素1β基因单核苷酸多态性及与生化指标的关系
Association of single nucleotide polymorphisms of IL-1βgene in schizophrenia patient and biochemistry indicators
摘要
Abstract
Objective To study the single nucleotide polymorphisms of rs146219183 in IL-1βgene in schizo-phrenia patients and healthy people ,to detect some biochemistry indicators in schizophrenia patients and to investigate the relation between these biochemistry indicators and the single nucleotide polymorphisms .Methods Firstly the se-quence of rs146219183 was inquired ,then the primers were designed and synthesized .After amplification the allele and genotype of each sample were obtained by sequencing .Then total 100 schizophrenia patients and 100 healthy peo-ple were genotyped by PCR test .Some clinical biochemical indicators of the liver function ,renal function and blood lipids were detected by the fully automatic biochemical analyzer .The differences among the patients with different al-leles and genotypes were statistically analyzed .Results The single nucleotide polymorphisms of rs146219183 in IL-1βgene in 100 schizophrenia patients and 100 healthy people was obtained .16 biochemical indicators were detected . The statistical analysis found that the AA ,AT and TT3 genotype frequency of rs146219183 had statistical difference between the schizophrenia patients and healthy people (χ2 =12 .054 7 ,P=0 .002 4) .The A and T allele frequency al-so had statistical difference(χ2 =8 .160 2 ,P=0 .004 3) .Among the three groups of patients with different genotypes of AA ,AT and TT3 ,the differences in biochemical indicator CA ,ALKP and GGT also had statistical significance . Conclusion The single nucleotide polymorphisms of rs146219183 in IL-1βgene is associated with schizophrenia .The differences of biochemical indicator CA ,ALKP and GGT exist in schizophrenia patients with different genotypes .关键词
精神分裂症/白细胞介素1β/SNP/基因型/生化指标Key words
schizophrenia/IL-1βgene/SNP/genotype/biochemical indicator引用本文复制引用
李立青,祝扬,宋瑞华,赵春海,王晓玲,潘莉..精神分裂症患者白细胞介素1β基因单核苷酸多态性及与生化指标的关系[J].检验医学与临床,2014,(21):2960-2962,3.基金项目
首都医学发展科研基金资助项目（2009-3-239）。 （）
