检验医学与临床Issue(21)：3008-3010,3.DOI:10.3969/j.issn.1672-9455.2014.21.025
β2受体激动剂与抗胆碱能药物治疗儿童哮喘的评价
Systematic review of β2 receptor agonists and anticholinergic drugs in children asthma
摘要
Abstract
Objective To evaluate the application of β2 receptor agonists ,anticholinergic drugs and β2 receptor agonists combined with anticholinergic drugs in children acute asthma .Methods The randomized controlled trials (RCTs)on the application ofβ2 receptor agonists and anticholinergic drugs in children asthma were retrieved from the Pubmed ,Embase and CJFD(from database establishment to now ) .The included RCTs were performed the quality e-valuation and data extraction .The Revman 5 .0 .2 software was adopted to conduct the statistical analysis .Results 14 RCTs involving 1028 patients were included .β2 receptor agonists was significantly superior to the anticholinergic drugs in the aspects of the treatment failure rate and the percentage of FEV 1 variation to the expected value at 60 min after treatment ,OR and 95% CI were 2 .27(95% CI:1 .08 -4 .75)and 12 .6(95% CI:6 .61 -18 .59) ,the hospitaliza-tion rate had no statistical difference between the two groups (P>0 .05) ,OR and 95% CI were 1 .11(95% CI:0 .66-1 .86) .β2 receptor agonists combined with anticholinergic drugs was significantly superior to the anticholinergic drugs treatment group in the aspects of the treatment failure rate ,hospitalization rate and the percentage of FEV 1 variation to the expected value at 60 min after treatment ,OR and 95% CI were 3 .67(95% CI:1 .41 -9 .50) ,2 .28(95% CI:1 .39-3 .73)and 10 .65(95% CI:5 .87 -15 .43) .Conclusion β2 receptor agonists and β2 receptor agonists combined with anticholinergic drugs have better efficacy on children acute asthma than single anticholinergic drugs .关键词
β2 受体激动剂/抗胆碱能药物/β2 受体激动剂联合抗胆碱能药物/儿童哮喘/急诊Key words
β2 receptor agonists/anticholinergic drugs/β2 receptor agonists combined with anticholinergic drugs/children asthma引用本文复制引用
郭梅,荆安龙..β2受体激动剂与抗胆碱能药物治疗儿童哮喘的评价[J].检验医学与临床,2014,(21):3008-3010,3.
