检验医学与临床Issue(22)：3142-3143,3146,3.DOI:10.3969/j.issn.1672-9455.2014.22.022
3项指标联合检测肝硬化的临床价值
Clinical value of combination detection of peripheral alpha fetoprotein,pyruvate kinase M2 and albumin in liver cirrhosis
李萍 1马健2
作者信息
- 1. 四川省成都市妇女儿童中心医院检验科 610031
- 2. 四川省成都市锦江区妇幼保健院检验科 610061
- 折叠
摘要
Abstract
Objective To investigate the clinical value of combination detection of peripheral alpha fetoprotein (AFP) ,pyruvate kinase M2(M2‐PK)and albumin(ALB) in the diagnosis of liver cirrhosis .Methods 178 cases of va‐rious liver diseases in the Chengdu Municipal Women and Children Central Hospital from March 2011 to March 2013 were divided into the acute hepatitis group(52 cases) ,chronic hepatitis group(57 cases)and liver cirrhosis group(69 cases)according to the types of disease;at the same period 60 individuals with healthy examination were selected as the control group .The serum levels of AFP ,M2‐PK and ALB were compared among 3 groups .Results Compared with the control group ,serum AFP ,M2‐PK levels in the acute hepatitis group ,the chronic hepatitis group and the cir‐rhosis group were significantly increased ,ALB was significantly decreased ,the difference was statistically significant (P<0 .05);compared with the other three groups ,serum AFP ,M2‐PK levels in the hepatic cirrhosis group were highest ,the serum ALB level was lowest(P<0 .05) .The serum AFP ,M2‐PK levels were increased with the increase of the Child‐Pugh grade ,and the serum level of ALB was decreased with the increase of the Child‐Pugh grade ,differ‐ences between them were statistically significant(P<0 .05) .The combined detection of AFP ,M2‐PK and ALB could improve the detection specificity and accuracy .Conclusion The combination detection of AFP ,M2‐PK and ALB has the higher clinical application value in the diagnosis of liver cirrhosis.关键词
甲胎蛋白/丙酮酸激酶M2/清蛋白/肝硬化Key words
alpha fetoprotein/pyruvate kinase M2/albumin/liver cirrhosis引用本文复制引用
李萍,马健..3项指标联合检测肝硬化的临床价值[J].检验医学与临床,2014,(22):3142-3143,3146,3.
