检验医学与临床Issue(23)：3279-3281,3.DOI:10.3969/j.issn.1672-9455.2014.23.019
急性心肌梗死患者血清蛋白电泳特点及其与预后的相关性研究
The characteristics of serum protein electrophoresis and their influence in patients with acute myocardial infarction
摘要
Abstract
Objective To analyze characteristics of serum protein electrophoresis(SPEP) and their influence in patients with acute myocardial infarction (AMI) .Methods A total of 50 patients diagnosed with AMI ,treated in Beijing Tiantan Hospital from 1th Jan .to 30th Jun .2013 ,were enrolled in this study .Clinical data ,including gender , age ,body mass index(BMI) ,medical history ,SPEP ,troponin(TNI) ,brain natriuretic peptide(BNP) ,left ventricular ejection fraction(LVEF) ,levels of serum glucose and lipid ,liver and kidney function ,length of stay in hospital and clinical outcome in 6 months(including death ,AMI ,heart failure ,malignant arrhythmia) were collected .The results of SPEP in patients with AMI were compared to those in healthy control group(50 cases) .Characteristics of SPEP and correlations between abnormal parameters of SPEP results and the length of stay in hospital ,clinical outcomes in 6 months were analyzed as well .Results In the AMI group ,the level of β1 globulin and the specific value of albumin and globulin(A/G) were decreased obviously ,while the ratio of β2 globulin andγ globulin in serum protein were in‐creased obviously ,with significant differences compared with the healthy control group(P<0 .05) .The Logistic anal‐ysis showed that there was significant correlation between A/G value and clinical outcomes in 6 month(P<0 .05) . Conclusion AMI could induce inflammatory reaction ,liver and kidney ischemia and decrease of liver cell synthesis function and glomerular filtrating function ,which could result in changes of serumβ1 ,β2 ,γglobulin and A/G value . And the increase of A/G value could predict poor prognosis .关键词
血清蛋白电泳/急性心肌梗死/β2 球蛋白/预后Key words
serum protein electrophoresis/acute myocardial infarction/β2 globulin/prognosis引用本文复制引用
付帅,王德昭..急性心肌梗死患者血清蛋白电泳特点及其与预后的相关性研究[J].检验医学与临床,2014,(23):3279-3281,3.基金项目
首都医科大学本科生科研创新项目（XSKY2013107）。 （）
