摘要
Abstract
Objective To study the effect of small‐dose remifentanil on suppressing cardiovascular responses to tracheal extubation after general anesthesia .Methods A total of 80 patients classified in ASA Ⅰ - Ⅱundergoing elective surgery under general anesthesia were enrolled in this study ,and randomly divided into observation group and control group ,with 40 cases in each group .The same induction and maintenance of anesthesia were given to the two groups .After operation remifentanil was continuously infused in the observation group ,and physiological saline was used in the control group as an alternative .Once the indication of tracheal extubation appeared ,tracheal extubation was conducted .The heart rate (HR) ,oxygen saturation (SpO2 ) ,systolic pressure (SBP) ,diastolic pressure (DBP) and other vital signs ,anesthesia recovery indicators and untoward reaction were recorded before tracheal extubation , tracheal extubation ,and 1 ,3 ,5 min after tracheal extubation .Results There were no significant differences of HR , SPO 2 ,SBP and DBP at the time of tracheal extubation ,and 1 ,3 ,5 min after tracheal extubation in the observation group ,compared with those before tracheal extubation(P>0 .05) ,while there were significant differences in the con‐trol group(P<0 .05) .There were significant differences of these indicators between observation group and control group at the time of tracheal extubation ,and 1 ,3 ,5 min after tracheal extubation(P<0 .05) .There were no signifi‐cant differences of spontaneous breathing recovery time ,the time of tracheal extubation and safe consciousness time compared between observation group and control group(P< 0 .05) .The incidence of untoward reaction in the ob‐served group(5 .0% ) was obviously lower than that in the control group(25 .0% ) ,with significant difference(P<0 . 05) .Conclusion Small‐dose remifentanil could effectively suppressing cardiovascular response to tracheal extuba‐tion ,with significant clinical effect and without obvious untoward reactions ,which would be worthy to widely use in clinical practice .关键词
瑞芬太尼/全麻/气管拔管/心血管反应/临床效果Key words
Remifentanil/general anesthesia/tracheal extubation/cardiovascular response/clinical effect
