检验医学与临床Issue(24)：3401-3402,2.DOI:10.3969/j.issn.1672-9455.2014.24.004
2012～2013年杭州市萧山区手足口病病原谱及临床特征分析
Analysis of pathogens spectrum and clinical characterization of hand,foot and mouth disease in Xiaoshan District of Hangzhou from 2012 to 2013
摘要
Abstract
Objective To understand the pathogens spectrum and clinical characterization of hand ,foot and mouth disease (HFMD) in Xiaoshan District of Hangzhou .Methods A total of 253 specimens ,including 208 stool specimens and 45 throat swabs ,collected from May .2012 to Jul .2013 were detected for pathogens of HFMD by using real‐time reverse transcriptase polymerase chain reaction assay .Results The positive rate of enterovirus (EV)was 83 .17% ,and the percentages of EV71 ,Coxsackie virus A16 (CoxA16) and other EV subtypes were 55 .49% , 13 .29% and 31 .21% ,respectively .The positive rates of EV were without significant difference between male and fe‐male children (P>0 .05) .EV71 was predominant strain in patients ,who were less than 5 years old ,and other EV subtypes were predominant strains in patients ,who were more than 5 years old .Fever with herpes was the main clini‐cal symptom in HFMD patients ,and EV71 was primary pathogen causing fever with herpes ,vomiting or neurological and so on .The positive rate of EV in stool specimens was significant higher than that in throat swabs (P<0 .05) . Conclusion EV71 and other EV subtypes might be predominant strains of HFMD ,and the prevalence of CoxA16 might be with downtrend .Detection of EV ,EV71 and CoxA16 could be important for the control and prevention of HFMD .关键词
手足口病/肠道病毒71型/柯萨奇病毒A16型Key words
hand ,foot and mouth disease/Enterovirus 71/Coxsackie virus A16引用本文复制引用
陈亮,李仪..2012～2013年杭州市萧山区手足口病病原谱及临床特征分析[J].检验医学与临床,2014,(24):3401-3402,2.基金项目
“十二五”国家科技重大专项（2012ZX10004-210）。 （）
