检验医学与临床Issue(24)：3415-3417,3.DOI:10.3969/j.issn.1672-9455.2014.24.010
细胞因子检测在急性胰腺炎患者中的临床意义
Clinical significance of cytokine alteration in patients with acute pancreatitis
摘要
Abstract
Objective To investigate the serum levels of interleukin‐1 (IL‐1) ,interleukin‐6 (IL‐6) and tumor necrosis factor‐α (TNF‐α) in patients with acute pancreatitis (AP) ,and to explore the role of cytokines for the as‐sessment of disease severity and prognosis. Methods During Jan. 2010 and Jan. 2013 ,58 AP patients ,with onset time of AP within 24 h ,were enrolled and divided into mild AP (MAP) group (39 cases) and severe AP (SAP) group (19 cases). Serum levels of TNF‐α,IL‐1 and IL‐6 were detected at 1 ,3 and 7 days after admission. The correlation of cy‐tokines with the acute physiology and chronic health evaluation (APACHEⅡ) score and CT severity index (CTSI) were also analyzed. Results Serum levels of TNF‐α,IL‐1 and IL‐6 were significantly higher in SAP group than those in MAP group (P<0. 01). In SAP group ,the concentrations of TNF‐α,IL‐1 and IL‐6 increased slightly in 3 days , though there were no statistical differences (P> 0. 05). However ,serum levels of TNF‐α,IL‐1 and IL‐6 at 7 days were significantly decreased ,compared with the corresponding levels at 1 and 3 days (P<0. 01). However ,these de‐clined serum levels of selected cytokines were still significantly higher than MAP group. In MAP group ,serum levels of TNF‐α,IL‐1 and IL‐6 decreased gradually and reached significant differences when compared with controls (P<0. 01). At the 7th day after admission ,serum concentrations of TNF‐α,IL‐1 and IL‐6 almost returned to the baseline. APACHEⅡ score and CTSI of SAP group were significantly higher than MAP group. In MAP group and SAP group ,serum levels of IL‐1 ,IL‐6 and TNF‐αwere positively correlated with APACHE Ⅱ score and CTSI at the 3rd day after admission (P<0. 01). Conclusion Detection of serum TNF‐α,IL‐1 and IL‐6 levels could be beneficial fro the assessment of disease severity and prognosis for AP.关键词
急性胰腺炎/细胞因子/白细胞介素-1/白细胞介素-6/肿瘤坏死因子-αKey words
acute pancreatitis/cytokine/interleukin-1/interleukin-6/tumor necrosis factor-α引用本文复制引用
王绪山,陈胜全,杨全德,刘景宏,王彪..细胞因子检测在急性胰腺炎患者中的临床意义[J].检验医学与临床,2014,(24):3415-3417,3.基金项目
江苏省连云港市卫生局科技支持项目（20121248）。 （）
