检验医学与临床Issue(z1)：69-71,3.DOI:10.3969/j.issn.1672-9455.2014.25.030
血清N端B型钠尿肽原、心肌肌钙蛋白I及C反应蛋白联合检测在心力衰竭诊断中的临床价值
The clinical value about the combined detection of the serum N-terminal pro-B-type natriuretic peptide,Cardiac troponin I and C reactive protein in the diagnosis of heart failure
宋杰 1白晶1
作者信息
- 1. 武警湖北总队医院检验科，湖北武汉 430061
- 折叠
摘要
Abstract
Objective To investigate the clinical value about the combined detection of the serum N terminal pro-B-type natriuretic peptide(NT-proBNP),cardiac troponin I(cTnI)and C reactive protein(CRP)in the diagnosis of heart failure(HF).Methods The serum levels of NT-proBNP,cTnI and CRP in 312 patients with different etio-logical factors and grades of HF[according to the cardiac function standard of New York Heart Association(NYHA)Ⅰ-Ⅳ]and 120 healthy controls were determined.The sensitivity and specificity of 3 parameters were evaluated by receiver operating characteristic (ROC)curve.Results The levels of NT-proBNP,cTnI and CRP in different grades of HF had statistical significant difference(P < 0.05).In addition,the grade was worse,and its concentration was higher.The levels of NT-proBNP,cTnI and CRP showed significant difference between HF NYHAⅠ grade patients and healthy people in control goup (P <0.05),and the level of cTnI had no significant difference(P >0.05).The sensitivity of combined detection was 92.6% in early HF diagnosis,which was significant higher than that of the in-dividual detection(P <0.01).Conclusion The combined detection of the serum NT-proBNP,cTnI and CRP provides reference support to the diagnosis of early HF.关键词
N 端B型钠尿肽原/心肌肌钙蛋白I/C反应蛋白/心力衰竭Key words
N terminal pro-B-type natriuretic peptide/cardiac troponin I/C reactive protein/heart fail-ure引用本文复制引用
宋杰,白晶..血清N端B型钠尿肽原、心肌肌钙蛋白I及C反应蛋白联合检测在心力衰竭诊断中的临床价值[J].检验医学与临床,2014,(z1):69-71,3.
